1401089-31-3

1401089-31-3 structure

Name: PACMA31
Chemical Name: PACMA 31
CAS Number: 1401089-31-3
Molecular Formula: C₂₁H₂₂N₂O₆S
Molecular Weight: 430.474
Create Date: 2020-01-11 08:07:41
Modify Date: 2024-01-10 13:46:16
An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI; significantly inhibits human ovarian cancer cells OVCAR-8, HEY, and OVCAR-8 growth with IC50 of 0.9, 1.4, and 0.32 uM; significantly suppresses ovarian tumor growth without causing toxicity to normal tissues in mouse xenograft model of human OVCAR-8 ovarian cancer.

Name	PACMA 31
Synonyms	MFCD26793891 Ethyl N-{[(2,4-dimethoxyphenyl)(propioloyl)amino](2-thienyl)acetyl}glycinate Glycine, N-[2-[(2,4-dimethoxyphenyl)(1-oxo-2-propyn-1-yl)amino]-2-(2-thienyl)acetyl]-, ethyl ester PACMA 31 N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester

Description	An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI; significantly inhibits human ovarian cancer cells OVCAR-8, HEY, and OVCAR-8 growth with IC50 of 0.9, 1.4, and 0.32 uM; significantly suppresses ovarian tumor growth without causing toxicity to normal tissues in mouse xenograft model of human OVCAR-8 ovarian cancer.
References	References 1. Xu S, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16348-53. 2. Vatolin S, et al. Cancer Res. 2016 Jun 1;76(11):3340-50. View Related Products by Target Protein Disulfide Isomerase (PDI)