PACMA31
Modify Date: 2024-01-10 13:46:16
PACMA31 structure
|
Common Name | PACMA31 | ||
|---|---|---|---|---|
| CAS Number | 1401089-31-3 | Molecular Weight | 430.474 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C21H22N2O6S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of PACMA31An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI; significantly inhibits human ovarian cancer cells OVCAR-8, HEY, and OVCAR-8 growth with IC50 of 0.9, 1.4, and 0.32 uM; significantly suppresses ovarian tumor growth without causing toxicity to normal tissues in mouse xenograft model of human OVCAR-8 ovarian cancer. |
| Name | PACMA 31 |
|---|---|
| Synonym | More Synonyms |
| Description | An orally active, irreversible inhibitor of protein disulfide isomerase (PDI), forming a covalent bond with the active site cysteines of PDI; significantly inhibits human ovarian cancer cells OVCAR-8, HEY, and OVCAR-8 growth with IC50 of 0.9, 1.4, and 0.32 uM; significantly suppresses ovarian tumor growth without causing toxicity to normal tissues in mouse xenograft model of human OVCAR-8 ovarian cancer. |
|---|---|
| References | References 1. Xu S, et al. Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16348-53. 2. Vatolin S, et al. Cancer Res. 2016 Jun 1;76(11):3340-50. View Related Products by Target Protein Disulfide Isomerase (PDI) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C21H22N2O6S |
| Molecular Weight | 430.474 |
| Exact Mass | 430.119843 |
| LogP | 1.50 |
| Index of Refraction | 1.592 |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| MFCD26793891 |
| Ethyl N-{[(2,4-dimethoxyphenyl)(propioloyl)amino](2-thienyl)acetyl}glycinate |
| Glycine, N-[2-[(2,4-dimethoxyphenyl)(1-oxo-2-propyn-1-yl)amino]-2-(2-thienyl)acetyl]-, ethyl ester |
| PACMA 31 |
| N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester |