1414938-21-8
1414938-21-8 structure
- Name: IRE1α-IN-3
- Chemical Name: 1-[4-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)-1-naphthyl]-3-[3-(trifluoromethyl)phenyl]urea
- CAS Number: 1414938-21-8
- Molecular Formula: C27H23F3N6O
- Molecular Weight: 504.506
- Create Date: 2020-01-19 22:55:55
- Modify Date: 2024-04-05 16:25:35
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IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM; demonstrates dose-dependent reduction of IRE1α kinase autophosphorylation amd inhibition of XBP1 RNA cleavage in the WT cell lines.
| Name | 1-[4-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)-1-naphthyl]-3-[3-(trifluoromethyl)phenyl]urea |
|---|---|
| Synonyms |
1-[4-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)-1-naphthyl]-3-[3-(trifluoromethyl)phenyl]urea
1-(4-(8-Amino-3-isopropylimidazo[1,5-a]pyrazin-1-yl)naphthalen-1-yl)-3-(3-(trifluoromethyl)phenyl)urea N-{4-[8-amino-3-(propan-2-yl)imidazo[1,5-a]pyrazin-1-yl]naphthalen-1-yl}-N'-[3-(trifluoromethyl)phenyl]urea Urea, N-[4-[8-amino-3-(1-methylethyl)imidazo[1,5-a]pyrazin-1-yl]-1-naphthalenyl]-N'-[3-(trifluoromethyl)phenyl]- |
| Description | IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM; demonstrates dose-dependent reduction of IRE1α kinase autophosphorylation amd inhibition of XBP1 RNA cleavage in the WT cell lines. |
|---|---|
| References | References 1. Wang L, et al. Nat Chem Biol. 2012 Dec;8(12):982-9. View Related Products by Target IRE1 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C27H23F3N6O |
| Molecular Weight | 504.506 |
| Exact Mass | 504.188538 |
| LogP | 5.92 |
| Index of Refraction | 1.660 |