1560968-55-9
1560968-55-9 structure
- Name: MIV-6R
- Chemical Name: 4-(3-{4-[(R)-Amino(cyclopentyl)phenylmethyl]-1-piperidinyl}propoxy)benzonitrile
- CAS Number: 1560968-55-9
- Molecular Formula: C27H35N3O
- Molecular Weight: 417.586
- Create Date: 2020-01-11 23:05:50
- Modify Date: 2024-01-19 18:08:47
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A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM; demonstrateds strong and selective effects in MLL leukemia cells, and induces more pronounced increase in CD11b expression in MLL-AF9 BMCs.
| Name | 4-(3-{4-[(R)-Amino(cyclopentyl)phenylmethyl]-1-piperidinyl}propoxy)benzonitrile |
|---|---|
| Synonyms |
4-(3-{4-[(R)-Amino(Cyclopentyl)phenylmethyl]piperidin-1-Yl}propoxy)benzonitrile
4-(3-{4-[(R)-Amino(cyclopentyl)phenylmethyl]-1-piperidinyl}propoxy)benzonitrile Benzonitrile, 4-[3-[4-[(R)-aminocyclopentylphenylmethyl]-1-piperidinyl]propoxy]- |
| Description | A potent, ligand-efficient, and cell-active inhibitor menin-MLL interaction with IC50 of 56 nM, Kd of 85 nM; demonstrateds strong and selective effects in MLL leukemia cells, and induces more pronounced increase in CD11b expression in MLL-AF9 BMCs. |
|---|---|
| References | References 1. Arkin MR, et al. Chem Biol. 2014 Sep 18;21(9):1102-14. 2. He S, et al. J Med Chem. 2014 Feb 27;57(4):1543-56. View Related Products by Target Histone Methyltransferase (HMTase) |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 591.4±35.0 °C at 760 mmHg |
| Molecular Formula | C27H35N3O |
| Molecular Weight | 417.586 |
| Flash Point | 311.5±25.9 °C |
| Exact Mass | 417.278015 |
| LogP | 5.70 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.601 |