1832713-02-6

1832713-02-6 structure

Name: RA 839
Chemical Name: (3S)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}-1-naphthyl)-3-pyrrolidinecarboxylic acid
CAS Number: 1832713-02-6
Molecular Formula: C₂₅H₂₈N₂O₄S
Molecular Weight: 452.566
Create Date: 2020-01-11 19:30:51
Modify Date: 2024-01-17 19:54:35
A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling; binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM; prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages; acutely induces Nrf2 target gene expression in liver in mice.

Name	(3S)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}-1-naphthyl)-3-pyrrolidinecarboxylic acid
Synonyms	MFCD30182350 (3s)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}naphthalen-1-Yl)pyrrolidine-3-Carboxylic Acid 3-Pyrrolidinecarboxylic acid, 1-[4-[[(2,3,5,6-tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-, (3S)- (3S)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}-1-naphthyl)-3-pyrrolidinecarboxylic acid

Description	A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling; binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM; prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages; acutely induces Nrf2 target gene expression in liver in mice.
References	References 1. Winkel AF, et al. J Biol Chem. 2015 Nov 20;290(47):28446-55. 2. Nasiri HR, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):526-529. View Related Products by Target Keap1-Nrf2