2117405-13-5

2117405-13-5 structure

Name: SEN-177
Chemical Name: SEN177
CAS Number: 2117405-13-5
Molecular Formula: C₁₈H₁₉FN₆
Molecular Weight: 338.382
Catalog: Research Areas Neurological Disease
Create Date: 2020-01-11 17:36:51
Modify Date: 2024-01-16 17:10:33
SEN177 is an inhibitor of glutaminyl cyclase (QPCT), thereby rescuing the Huntington's disease (HD)-related phenotypes in cell.

Name	SEN177
Synonyms	3',3'']terpyridine SEN177 MFCD30343871 Piperidine, 1-(6'-fluoro[3,3'-bipyridin]-2-yl)-4-(4-methyl-4H-1,2,4-triazol-3-yl)- 6'-Fluoro-2-[4-(4-methyl-4H-1,2,4-triazol-3-yl)-1-piperidinyl]-3,3'-bipyridine 6''-Fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2' 6''-fluoro-4-(4-methyl-4H-[1,2,4]triazol-3-yl)-3,4,5,6-tetrahydro-2H-[1,2';3',3'']terpyridine

Description	SEN177 is an inhibitor of glutaminyl cyclase (QPCT), thereby rescuing the Huntington's disease (HD)-related phenotypes in cell.
In Vitro	SEN177 is a Glutaminyl cyclase (QPCT) inhibitor. Glutaminyl cyclase modifies N-terminal glutamine or glutamate residues to N-terminal 5-oxoproline or pyroglutamate (named QPCT). QPCT inhibits mutant huntingtin from forming aggregates, but also reduces aggregation of other aggregate-prone proteins containing polyQ or polyA repeats. SEN177 caused dose-dependent decreases in HTT aggregation by a mechanism that requires QPCT inhibition. SEN177 had in vitro activity against polyglutamine toxicity and was able to reduce aggregates in mammalian cells, primary neurons and in a Drosophila model.