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300803-69-4

300803-69-4 structure
300803-69-4 structure
  • Name: OB-1
  • Chemical Name: Ethyl 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-1-benzofuran-3-carboxylate
  • CAS Number: 300803-69-4
  • Molecular Formula: C21H17N3O6
  • Molecular Weight: 407.376
  • Catalog: Research Areas Neurological Disease
  • Create Date: 2020-01-12 09:45:45
  • Modify Date: 2024-01-09 19:31:49
  • A small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo; also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity.

Name Ethyl 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-1-benzofuran-3-carboxylate
Synonyms MFCD01462999
3-Benzofurancarboxylic acid, 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-, ethyl ester
Ethyl 5-[(1-methyl-4-nitro-1H-imidazol-5-yl)oxy]-2-phenyl-1-benzofuran-3-carboxylate
Description A small-molecule inhibitor of STOML3 oligomerization that reverses pathological mechanical hypersensitivity in vivo; effectively inhibits the self-association of stomatin, STOML1 and STOML2 at 2 uM, but not podocin; reversibly reduces the sensitivity of mechanically gated currents in sensory neurons and silence mechanoreceptors in vivo; also reversibly attenuates fine touch perception in normal mice, reverses pathological mechanical hypersensitivity.
References References 1. Wetzel C, et al. Nat Neurosci. 2017 Feb;20(2):209-218. View Related Products by Target Other Targets
Density 1.4±0.1 g/cm3
Boiling Point 628.5±55.0 °C at 760 mmHg
Molecular Formula C21H17N3O6
Molecular Weight 407.376
Flash Point 333.9±31.5 °C
Exact Mass 407.111725
LogP 5.15
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.649