313994-79-5
313994-79-5 structure
- Name: CMPD167
- Chemical Name: MRK-1
- CAS Number: 313994-79-5
- Molecular Formula: C35H47FN4O2
- Molecular Weight: 574.772
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2020-01-19 21:06:56
- Modify Date: 2024-09-24 21:16:02
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CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM).
| Name | MRK-1 |
|---|---|
| Synonyms |
N-[(1R,3S,4S)-3-{[4-(3-Benzyl-1-ethyl-1H-pyrazol-5-yl)-1-piperidinyl]methyl}-4-(3-fluorophenyl)cyclopentyl]-N-methyl-D-valine
D-Valine, N-[(1R,3S,4S)-3-[[4-[1-ethyl-3-(phenylmethyl)-1H-pyrazol-5-yl]-1-piperidinyl]methyl]-4-(3-fluorophenyl)cyclopentyl]-N-methyl- MRK-1 |
| Description | CMPD167 (MRK-1) is an orally acitve small molecule that binds to CCR5 to inhibit gp120 association, inhibits different stages of the virus-cell attachment and entry process (CCR5-using virus SHIV-162P3, IC50<1 nM). |
|---|---|
| References | References 1. Veazey RS, et al. Nature. 2005 Nov 3;438(7064):99-102. 2. Veazey RS, et al. Nat Med. 2005 Dec;11(12):1293-4. 3. Ketas TJ, et al. Virology. 2007 Aug 1;364(2):431-40. 4. Malcolm RK, et al. Antimicrob Agents Chemother. 2012 May;56(5):2251-8. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 694.4±55.0 °C at 760 mmHg |
| Molecular Formula | C35H47FN4O2 |
| Molecular Weight | 574.772 |
| Flash Point | 373.8±31.5 °C |
| Exact Mass | 574.368286 |
| LogP | 6.27 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.607 |