404011-02-5

404011-02-5 structure

Name: IC 87361
Chemical Name: 5-Hydroxy-7-(4-morpholinyl)-2-phenyl-4H-chromen-4-one
CAS Number: 404011-02-5
Molecular Formula: C₁₉H₁₇NO₄
Molecular Weight: 323.343
Create Date: 2020-01-12 13:16:51
Modify Date: 2024-04-03 08:06:35
IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β; enhances radiation sensitivity in wild-type C57BL6 endothelial cells; induces radiosensitization of tumor microvasculature in wild-type mice.

Name	5-Hydroxy-7-(4-morpholinyl)-2-phenyl-4H-chromen-4-one
Synonyms	4H-1-Benzopyran-4-one, 5-hydroxy-7-(4-morpholinyl)-2-phenyl- 5-Hydroxy-7-(4-morpholinyl)-2-phenyl-4H-chromen-4-one

Description	IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β; enhances radiation sensitivity in wild-type C57BL6 endothelial cells; induces radiosensitization of tumor microvasculature in wild-type mice.
References	References 1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64. 2. Shinohara ET, et al. Cancer Res. 2005 Jun 15;65(12):4987-92. View Related Products by Target DNA-PK