404011-02-5
404011-02-5 structure
- Name: IC 87361
- Chemical Name: 5-Hydroxy-7-(4-morpholinyl)-2-phenyl-4H-chromen-4-one
- CAS Number: 404011-02-5
- Molecular Formula: C19H17NO4
- Molecular Weight: 323.343
- Create Date: 2020-01-12 13:16:51
- Modify Date: 2024-04-03 08:06:35
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IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β; enhances radiation sensitivity in wild-type C57BL6 endothelial cells; induces radiosensitization of tumor microvasculature in wild-type mice.
| Name | 5-Hydroxy-7-(4-morpholinyl)-2-phenyl-4H-chromen-4-one |
|---|---|
| Synonyms |
4H-1-Benzopyran-4-one, 5-hydroxy-7-(4-morpholinyl)-2-phenyl-
5-Hydroxy-7-(4-morpholinyl)-2-phenyl-4H-chromen-4-one |
| Description | IC 87361 is a potent and selective DNA-PK inhibitor with IC50 of 34 nM, shows >50-fold selectivity over p110β; enhances radiation sensitivity in wild-type C57BL6 endothelial cells; induces radiosensitization of tumor microvasculature in wild-type mice. |
|---|---|
| References | References 1. Kashishian A, et al. Mol Cancer Ther. 2003 Dec;2(12):1257-64. 2. Shinohara ET, et al. Cancer Res. 2005 Jun 15;65(12):4987-92. View Related Products by Target DNA-PK |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 590.4±50.0 °C at 760 mmHg |
| Molecular Formula | C19H17NO4 |
| Molecular Weight | 323.343 |
| Flash Point | 310.9±30.1 °C |
| Exact Mass | 323.115753 |
| LogP | 2.21 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.650 |