425666-42-8

425666-42-8 structure

Name: TKDC
Chemical Name: N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide
CAS Number: 425666-42-8
Molecular Formula: C₁₈H₁₉ClN₂O₃S
Molecular Weight: 378.873
Create Date: 2020-01-12 12:02:35
Modify Date: 2024-01-09 21:09:29
TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively; maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively; decreases immobility and induces antidepressant-like effects in mice.

Name	N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide
Synonyms	Methanesulfonamide, N-(4-chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]- N-(4-chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide

Description	TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively; maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively; decreases immobility and induces antidepressant-like effects in mice.
References	References 1. Luo Q, et al. Nat Commun. 2017 Aug 29;8(1):378. View Related Products by Target Potassium Channel