TKDC
Modify Date: 2024-01-09 21:09:29
TKDC structure
|
Common Name | TKDC | ||
|---|---|---|---|---|
| CAS Number | 425666-42-8 | Molecular Weight | 378.873 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 588.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C18H19ClN2O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 309.5±32.9 °C | |
Use of TKDCTKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively; maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively; decreases immobility and induces antidepressant-like effects in mice. |
| Name | N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | TKDC is a small molecule allosteric inhibitor of TREK channels with IC50 of 4.9, 5.2 and 65.9 uM for TREK-1, TREK-2 and TRAAK, respectively; maintains potency for mutant TREK-1 channels with IC50 of 2.4, 2.4 and 2.2 uM for T79A TREK-1, Q83A TREK-1 and Q105A TREK-1, respectively; decreases immobility and induces antidepressant-like effects in mice. |
|---|---|
| References | References 1. Luo Q, et al. Nat Commun. 2017 Aug 29;8(1):378. View Related Products by Target Potassium Channel |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 588.2±60.0 °C at 760 mmHg |
| Molecular Formula | C18H19ClN2O3S |
| Molecular Weight | 378.873 |
| Flash Point | 309.5±32.9 °C |
| Exact Mass | 378.080475 |
| LogP | 3.45 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.640 |
| Methanesulfonamide, N-(4-chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]- |
| N-(4-chlorophenyl)-N-[2-(3,4-dihydroisoquinolin-2(1H)-yl)-2-oxoethyl]methanesulfonamide |
| N-(4-Chlorophenyl)-N-[2-(3,4-dihydro-2(1H)-isoquinolinyl)-2-oxoethyl]methanesulfonamide |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: WAY-297344
- Price: Negotiable
- Purity: 97.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: TKDC
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: TKDC
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
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