582332-31-8
582332-31-8 structure
- Name: UK-500001
- Chemical Name: UK-500001
- CAS Number: 582332-31-8
- Molecular Formula: C26H24F3N3O4
- Molecular Weight: 499.482
- Create Date: 2020-01-12 10:55:32
- Modify Date: 2024-02-07 23:21:34
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A potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively.
| Name | UK-500001 |
|---|---|
| Synonyms |
2-(3,4-Difluorophenoxy)-5-fluoro-N-{cis-4-[(2-hydroxy-5-methylbenzoyl)amino]cyclohexyl}nicotinamide
3-Pyridinecarboxamide, 2-(3,4-difluorophenoxy)-5-fluoro-N-[cis-4-[(2-hydroxy-5-methylbenzoyl)amino]cyclohexyl]- YOG0PR3Q8J UK-500001 |
| Description | A potent, selective phosphodiesterase 4 (PDE4) inhibitor with IC50 of 26.1, 22.8, 21 and 0.28 nM for PDE4A4, PDE4B2, PDE4C2 and PDE4D3, respectively. |
|---|---|
| References | References 1. Moretto N, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):559-67. 2. Vestbo J, et al. Eur Respir J. 2009 May;33(5):1039-44. View Related Products by Target Phosphodiesterase (PDE) |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 632.2±55.0 °C at 760 mmHg |
| Molecular Formula | C26H24F3N3O4 |
| Molecular Weight | 499.482 |
| Flash Point | 336.1±31.5 °C |
| Exact Mass | 499.171906 |
| LogP | 5.12 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.619 |