654080-03-2
654080-03-2 structure
- Name: SK 216
- Chemical Name: Disodium [5-({6-[5-(2-methyl-2-propanyl)-1,3-benzoxazol-2-yl]-2-naphthyl}oxy)pentyl]malonate
- CAS Number: 654080-03-2
- Molecular Formula: C29H29NO6Na2
- Molecular Weight: 533.523
- Create Date: 2020-01-12 07:47:28
- Modify Date: 2024-01-05 17:35:58
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SK 216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM; reduces the size of subcutaneous tumors and the extent of metastases in mice tumor model, also reduces the extent of angiogenesis in the tumors and inhibits VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro.
| Name | Disodium [5-({6-[5-(2-methyl-2-propanyl)-1,3-benzoxazol-2-yl]-2-naphthyl}oxy)pentyl]malonate |
|---|---|
| Synonyms |
Propanedioic acid, 2-[5-[[6-[5-(1,1-dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]-, sodium salt (1:2)
Disodium [5-({6-[5-(2-methyl-2-propanyl)-1,3-benzoxazol-2-yl]-2-naphthyl}oxy)pentyl]malonate |
| Description | SK 216 is a potent, selective inhibitor of plasminogen activator inhibitor-1 (PAI-1) with IC50 of 44 uM; reduces the size of subcutaneous tumors and the extent of metastases in mice tumor model, also reduces the extent of angiogenesis in the tumors and inhibits VEGF-induced migration and tube formation by human umbilical vein endothelial cells in vitro. |
|---|---|
| References | References 1. Masuda T, et al. Mol Cancer Ther. 2013 Nov;12(11):2378-88. 2. Mutoh M, et al. Carcinogenesis. 2008 Apr;29(4):824-9. 3. Takayama Y, et al. Cancer Res. 2016 Jun 1;76(11):3285-94. View Related Products by Target Plasminogen Activator Inhibitor-1 (PAI-1) |
| Molecular Formula | C29H29NO6Na2 |
|---|---|
| Molecular Weight | 533.523 |
| Exact Mass | 533.179016 |