875927-64-3

875927-64-3 structure

Name: UoS 12258
Chemical Name: N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
CAS Number: 875927-64-3
Molecular Formula: C₁₇H₁₉FN₂O₂S
Molecular Weight: 334.408
Create Date: 2020-01-11 17:23:29
Modify Date: 2024-04-11 09:33:16
UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6; displays excellent wide selectivity against a wide range of other ion channels (including hERG, NMDA, and kainate channels), enzymes, and GPCRs; displays a minimum effective concentration of approximately 10 nM in vitro and enhances AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of approximately 15 nM in vivo; exhibits cognition enhancing properties in several rat behavioural models.

Name	N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide
Synonyms	2-Propanesulfonamide, N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]- N-[(2S)-5-(6-Fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide

Description	UoS12258 (UoS-12258) is a selective, positive allosteric modulator of the AMPA receptor with pEC50 of 5.6; displays excellent wide selectivity against a wide range of other ion channels (including hERG, NMDA, and kainate channels), enzymes, and GPCRs; displays a minimum effective concentration of approximately 10 nM in vitro and enhances AMPA receptor-mediated synaptic transmission at an estimated free brain concentration of approximately 15 nM in vivo; exhibits cognition enhancing properties in several rat behavioural models.
References	References 1. Ward SE, et al. J Med Chem. 2010 Aug 12;53(15):5801-12. 2. Ward SE, et al. Br J Pharmacol. 2017 Mar;174(5):370-385. View Related Products by Target iGluR