1550053-02-5

1550053-02-5 structure

Name: BRD3308
Chemical Name: BRD3308
CAS Number: 1550053-02-5
Molecular Formula: C₁₅H₁₄FN₃O₂
Molecular Weight: 287.289
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2020-01-11 13:01:03
Modify Date: 2024-01-08 06:53:10
BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms; attenuates PE-mediated phosphorylation of ERK, but not JNK; also activates HIV-1 transcription in the 2D10 cell line, induces outgrowth of HIV-1 from resting CD4+ T cells isolated from antiretroviral-treated, aviremic HIV+ patients ex vivo and disrupts HIV-1 latency; suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release.

Name	BRD3308
Synonyms	BRD3308 Benzamide, 4-(acetylamino)-N-(2-amino-4-fluorophenyl)- 4-Acetamido-N-(2-amino-4-fluorophenyl)benzamide MFCD30187588

Description	BRD3308 is a potent, selective HDAC3 inhibitor with IC50 of 54 nM, displays >20-fold selectivity over HDAC1 and HDAC2, >500-fold selectivity over other HDAC isoforms; attenuates PE-mediated phosphorylation of ERK, but not JNK; also activates HIV-1 transcription in the 2D10 cell line, induces outgrowth of HIV-1 from resting CD4+ T cells isolated from antiretroviral-treated, aviremic HIV+ patients ex vivo and disrupts HIV-1 latency; suppresses pancreatic β-cell apoptosis induced by inflammatory cytokines or glucolipotoxic stress, and increases functional insulin release.
References	References 1. Ferguson BS, et al. Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9806-11. 2. Barton KM, et al. PLoS One. 2014 Aug 19;9(8):e102684. 3. Wagner FF, et al. ACS Chem Biol. 2016 Feb 19;11(2):363-74. View Related Products by Target HDAC