1821638-40-7

1821638-40-7 structure

Name: LUF7346
Chemical Name: LUF7346
CAS Number: 1821638-40-7
Molecular Formula: C₂₀H₁₅BrN₂O₃
Molecular Weight: 411.249
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
Create Date: 2020-01-11 13:07:34
Modify Date: 2024-09-22 11:24:37
LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation; rescues the genetic form of LQTS, reverses drug-induced LQTS and correct thes combination of genetic and drug-induced LQTS; normalises both action- and field potentials (AP and FP, respectively) in all hPSC-CMs by slowing IKr deactivation and positively shifting the IKr inactivation.

Name	LUF7346
Synonyms	LUF7346 Acetamide, 2-[4-(2-bromobenzoyl)phenoxy]-N-3-pyridinyl- 2-[4-(2-BROMOBENZOYL)PHENOXY]-N-(PYRIDIN-3-YL)ACETAMIDE 2-[4-(2-Bromobenzoyl)phenoxy]-N-(3-pyridinyl)acetamide

Description	LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation; rescues the genetic form of LQTS, reverses drug-induced LQTS and correct thes combination of genetic and drug-induced LQTS; normalises both action- and field potentials (AP and FP, respectively) in all hPSC-CMs by slowing IKr deactivation and positively shifting the IKr inactivation.
References	References 1. Sala L, et al. EMBO Mol Med. 2016 Sep 1;8(9):1065-81. 2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9. 3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel