1821638-40-7
1821638-40-7 structure
- Name: LUF7346
- Chemical Name: LUF7346
- CAS Number: 1821638-40-7
- Molecular Formula: C20H15BrN2O3
- Molecular Weight: 411.249
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel Potassium Channel
- Create Date: 2020-01-11 13:07:34
- Modify Date: 2024-09-22 11:24:37
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LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation; rescues the genetic form of LQTS, reverses drug-induced LQTS and correct thes combination of genetic and drug-induced LQTS; normalises both action- and field potentials (AP and FP, respectively) in all hPSC-CMs by slowing IKr deactivation and positively shifting the IKr inactivation.
| Name | LUF7346 |
|---|---|
| Synonyms |
LUF7346
Acetamide, 2-[4-(2-bromobenzoyl)phenoxy]-N-3-pyridinyl- 2-[4-(2-BROMOBENZOYL)PHENOXY]-N-(PYRIDIN-3-YL)ACETAMIDE 2-[4-(2-Bromobenzoyl)phenoxy]-N-(3-pyridinyl)acetamide |
| Description | LUF7346 is a novel hERG allosteric modulator that slows IKr deactivation and positively shifting IKr inactivation; rescues the genetic form of LQTS, reverses drug-induced LQTS and correct thes combination of genetic and drug-induced LQTS; normalises both action- and field potentials (AP and FP, respectively) in all hPSC-CMs by slowing IKr deactivation and positively shifting the IKr inactivation. |
|---|---|
| References | References 1. Sala L, et al. EMBO Mol Med. 2016 Sep 1;8(9):1065-81. 2. Yu Z, et al. Eur J Med Chem. 2015 Dec 1;106:50-9. 3. Yu Z, et al. Circ Arrhythm Electrophysiol. 2016 Apr;9(4):e003439. View Related Products by Target Potassium Channel |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 632.5±50.0 °C at 760 mmHg |
| Molecular Formula | C20H15BrN2O3 |
| Molecular Weight | 411.249 |
| Flash Point | 336.3±30.1 °C |
| Exact Mass | 410.026611 |
| LogP | 3.35 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.656 |