2101952-78-5
2101952-78-5 structure
- Name: CYP11B1-IN-25
- Chemical Name: 3-Methoxy-5-[(3-phenyl-1,2-oxazol-5-yl)methyl]pyridine
- CAS Number: 2101952-78-5
- Molecular Formula: C16H14N2O2
- Molecular Weight: 266.295
- Create Date: 2020-01-11 18:59:05
- Modify Date: 2024-10-03 18:15:30
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CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2; inhibits rat CYP11B1 in V79MZ cells expressing recombinant rat CYP11B1 with IC50 of 1.8 uM; shows a high oral bioavailability (F = 50%) and sufficient plasma concentrations in rats, improved pharmacological profile for treatment of Cushing's disease.
| Name | 3-Methoxy-5-[(3-phenyl-1,2-oxazol-5-yl)methyl]pyridine |
|---|---|
| Synonyms |
3-Methoxy-5-[(3-phenyl-1,2-oxazol-5-yl)methyl]pyridine
Pyridine, 3-methoxy-5-[(3-phenyl-5-isoxazolyl)methyl]- |
| Description | CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2; inhibits rat CYP11B1 in V79MZ cells expressing recombinant rat CYP11B1 with IC50 of 1.8 uM; shows a high oral bioavailability (F = 50%) and sufficient plasma concentrations in rats, improved pharmacological profile for treatment of Cushing's disease. |
|---|---|
| References | References 1. Emmerich J, et al. J Med Chem. 2017 Jun 22;60(12):5086-5098. View Related Products by Target Cytochrome P450 (CYPs) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 455.6±40.0 °C at 760 mmHg |
| Molecular Formula | C16H14N2O2 |
| Molecular Weight | 266.295 |
| Flash Point | 229.4±27.3 °C |
| Exact Mass | 266.105530 |
| LogP | 2.53 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.577 |