CYP11B1-IN-25

Modify Date: 2024-10-03 18:15:30

CYP11B1-IN-25 Structure
CYP11B1-IN-25 structure
Common Name CYP11B1-IN-25
CAS Number 2101952-78-5 Molecular Weight 266.295
Density 1.2±0.1 g/cm3 Boiling Point 455.6±40.0 °C at 760 mmHg
Molecular Formula C16H14N2O2 Melting Point N/A
MSDS N/A Flash Point 229.4±27.3 °C

 Use of CYP11B1-IN-25


CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2; inhibits rat CYP11B1 in V79MZ cells expressing recombinant rat CYP11B1 with IC50 of 1.8 uM; shows a high oral bioavailability (F = 50%) and sufficient plasma concentrations in rats, improved pharmacological profile for treatment of Cushing's disease.

 Names

Name 3-Methoxy-5-[(3-phenyl-1,2-oxazol-5-yl)methyl]pyridine
Synonym More Synonyms

 CYP11B1-IN-25 Biological Activity

Description CYP11B1-IN-25 is a selective, potent 11β-hydroxylase (CYP11B1) inhibitor with IC50 of 2 nM, displays 14-fold selectivity over CYP11B2; inhibits rat CYP11B1 in V79MZ cells expressing recombinant rat CYP11B1 with IC50 of 1.8 uM; shows a high oral bioavailability (F = 50%) and sufficient plasma concentrations in rats, improved pharmacological profile for treatment of Cushing's disease.
References References 1. Emmerich J, et al. J Med Chem. 2017 Jun 22;60(12):5086-5098. View Related Products by Target Cytochrome P450 (CYPs)

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 455.6±40.0 °C at 760 mmHg
Molecular Formula C16H14N2O2
Molecular Weight 266.295
Flash Point 229.4±27.3 °C
Exact Mass 266.105530
LogP 2.53
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.577

 Synonyms

3-Methoxy-5-[(3-phenyl-1,2-oxazol-5-yl)methyl]pyridine
Pyridine, 3-methoxy-5-[(3-phenyl-5-isoxazolyl)methyl]-
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