1443735-02-1
1443735-02-1 structure
- Name: ROMK-IN-25
- Chemical Name: ROMK-IN-25
- CAS Number: 1443735-02-1
- Molecular Formula: C23H23FN8O2
- Molecular Weight: 462.489
- Create Date: 2020-01-11 21:09:50
- Modify Date: 2024-02-06 19:53:08
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ROMK-IN-25 is a potent and selective ROMK channel (KCNJ1) inhibitor with IC50 of 72 nM; displays improved ROMK/hERG selectivity (866-fold over hERG), and improved pharmacokinetic profiles; does not evoke QTc prolongation in an in vivo cardiovascular dog model.
| Name | ROMK-IN-25 |
|---|
| Description | ROMK-IN-25 is a potent and selective ROMK channel (KCNJ1) inhibitor with IC50 of 72 nM; displays improved ROMK/hERG selectivity (866-fold over hERG), and improved pharmacokinetic profiles; does not evoke QTc prolongation in an in vivo cardiovascular dog model. |
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| References | References 1. Zhu Y, et al. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5695-5702. View Related Products by Target Potassium Channel |
| Molecular Formula | C23H23FN8O2 |
|---|---|
| Molecular Weight | 462.489 |