2490538-46-8
2490538-46-8 structure
- Name: Tubulin polymerization-IN-25
- Chemical Name: Tubulin polymerization-IN-25
- CAS Number: 2490538-46-8
- Molecular Formula: C24H18N2O3S
- Molecular Weight: 414.48
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
- Create Date: 2022-08-05 12:59:42
- Modify Date: 2024-01-25 22:50:40
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Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity [1].
| Name | Tubulin polymerization-IN-25 |
|---|
| Description | Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor of tubulin polymerization and farnesyl transferase (FTase) with IC50s of 1.11 μM and 0.39 μM, respectively. Tubulin polymerization-IN-25 displays cytotoxicity and excellent antitumor activity [1]. |
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| Related Catalog | |
| Target |
IC50: 1.11 μM (Tubulin); 0.39 μM (FTase)[1] |
| In Vitro | Tubulin polymerization-IN-25 (compound 17f) is a dual inhibitor (MTI-FTI hybrids) acting on tubulin polymerization and on FTase[1]. Tubulin polymerization-IN-25 (10 μM, 48 h) inhibits cells growth and induces cell cytotoxicity on multiple cancer cell lines[1]. Cell Viability Assay[1] Cell Line: Leukemia cells: SR, CCRF-CEM, K-562; lung cancer cell CCRF-CEMNCI-H522; melanoma cell M14 Concentration: 10 μM Incubation Time: 48 hours Result: Inhibited cell growth. Cell Cytotoxicity Assay[1] Cell Line: NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer) Concentration: 10 μM Incubation Time: 48 hours Result: Induced cell cytotoxicity. |
| References |
| Molecular Formula | C24H18N2O3S |
|---|---|
| Molecular Weight | 414.48 |