503537-33-5

503537-33-5 structure

Name: BL-1020
Chemical Name: PERPHENAZINE 4-AMINOBUTYRATE
CAS Number: 503537-33-5
Molecular Formula: C₂₅H₃₄Cl₂N₄O₂S
Molecular Weight: 489.073
Create Date: 2020-01-11 17:27:58
Modify Date: 2024-01-10 19:47:33
BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist; reduces dopamine activity and enhances GABAA activity, shows pro-cognitive effects and potential for the treatment of schizophrenia; displays strong dopamine and serotonin (5HT) receptor inhibition ((D2LK(iz)=0.066 nM, D(2S)Ki=0.062 nM, 5-HT2A Ki=0.21 nM). Schizophrenia Phase 2 Discontinued

Name	PERPHENAZINE 4-AMINOBUTYRATE
Synonyms	Butanoic acid, 4-amino-, 2-[4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl]ethyl ester PERPHENAZINE 4-AMINOBUTYRATE 2-{4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazinyl}ethyl 4-aminobutanoate

Description	BL-1020 is an ester of GABA and perphenazine, fuctions as orally-active antipsychotic agent and acts as a D2 antagonist and GABA agonist; reduces dopamine activity and enhances GABAA activity, shows pro-cognitive effects and potential for the treatment of schizophrenia; displays strong dopamine and serotonin (5HT) receptor inhibition ((D2LK(iz)=0.066 nM, D(2S)Ki=0.062 nM, 5-HT2A Ki=0.21 nM). Schizophrenia Phase 2 Discontinued
References	References 1. Geffen Y, et al. Eur Neuropsychopharmacol. 2009 Jan;19(1):1-13. 2. Nudelman A, et al. J Med Chem. 2008 May 8;51(9):2858-62. 3. Appel L, et al. Eur Neuropsychopharmacol. 2009 Dec;19(12):841-50. 4. Geffen Y, et al. J Clin Psychiatry. 2012 Sep;73(9):e1168-74. View Related Products by Target Dopamine Receptor Schizophrenia