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1644029-01-5

1644029-01-5 structure
1644029-01-5 structure
  • Name: RORγt inverse agonist 22
  • Chemical Name: RORγt inverse agonist 22
  • CAS Number: 1644029-01-5
  • Molecular Formula: C23H25F2N3O5Si
  • Molecular Weight: 489.551
  • Create Date: 2020-01-11 18:44:50
  • Modify Date: 2024-04-05 19:32:29
  • RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ; exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors; demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration.

Name RORγt inverse agonist 22
Description RORγt inverse agonist 22 is a potent, subtype selective RORγt inverse agonist with binding IC50 of 18 nM, displays >192-fold selectivity over RORα and RORβ; exhibits cellular potency in RORγt reporter gene assays with IC50 of 13 nM, also shows >250-fold selectivity over a panel of 20 nuclear receptors; demonstrates in vivo potency to suppress the transcriptional activity of RORγt in a mouse PD model upon oral administration.
References References 1. Shirai J, et al. Bioorg Med Chem. 2018 Jan 15;26(2):483-500. View Related Products by Target ROR
Molecular Formula C23H25F2N3O5Si
Molecular Weight 489.551