1280204-67-2
1280204-67-2 structure
- Name: PI3K-IN-8q
- Chemical Name: PI3K-IN-8q
- CAS Number: 1280204-67-2
- Molecular Formula: C23H23FN8O
- Molecular Weight: 446.49
- Create Date: 2020-01-11 20:01:50
- Modify Date: 2024-10-03 19:14:52
-
PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively; exhibits high selectivity over p110α and p110β (Ki>490 nM); inhibits p-Akt with EC50 of 50 nM, and p110α with IC50 of 0.5 nM; has promising in vivo PK data; orally bioavailable.
| Name | PI3K-IN-8q |
|---|
| Description | PI3K-IN-8q is a potent, selective dual p110α/p110δ inhibitor with Ki app of 3.3/8.36 nM respectively; exhibits high selectivity over p110α and p110β (Ki>490 nM); inhibits p-Akt with EC50 of 50 nM, and p110α with IC50 of 0.5 nM; has promising in vivo PK data; orally bioavailable. |
|---|---|
| References | References 1. Martínez González S, et al. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2536-2543. View Related Products by Target PI3K |
| Molecular Formula | C23H23FN8O |
|---|---|
| Molecular Weight | 446.49 |