1425049-26-8
1425049-26-8 structure
- Name: RB-011
- Chemical Name: RB-011
- CAS Number: 1425049-26-8
- Molecular Formula: C21H36N+
- Molecular Weight: 302.525
- Create Date: 2020-01-16 16:06:12
- Modify Date: 2024-03-02 11:47:06
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A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells; ahs ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo; exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing.
| Name | RB-011 |
|---|
| Description | A small molecule that disrupt 14-3-3 dimers at low micromolar concentrations and induce rapid down-regulation of Raf-MAPK and PI3K-Akt signaling in Jurkat cells; ahs ED50 of 3 uM for apoptosis induction in Jurkat cells, inhibits A549 lung cancer cell growth in vitro and in vivo; exhibits a rounded morphology similar to that of 14-3-3ζ KO dermal fibroblasts, increasing signal flux through the ROCK pathway, impairing the ECM remodeling, and accelerating wound healing. |
|---|---|
| References | References 1. Woodcock JM, et al. Oncotarget. 2015 Jun 10;6(16):14522-36. 2. Kular J, et al. Dev Cell. 2015 Dec 21;35(6):759-74. View Related Products by Target 14-3-3 Protein |
| Molecular Formula | C21H36N+ |
|---|---|
| Molecular Weight | 302.525 |