1802937-26-3
1802937-26-3 structure
- Name: JP-153
- Chemical Name: JP-153
- CAS Number: 1802937-26-3
- Molecular Formula: C21H19NO5
- Molecular Weight: 365.385
- Create Date: 2020-01-11 15:23:50
- Modify Date: 2023-02-15 23:24:25
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JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model.
| Name | JP-153 |
|---|
| Description | JP-153 (JP153) is a novel small molecule targets the Src-FAK-Paxillin signaling, inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) in RECs; potently inhibits VEGF-induced proliferation and migration, inhibits retinal neovascularization in the murine oxygen-induced retinopathy model. |
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| References | References 1. Toutounchian JJ, et al. Mol Pharmacol. 2017 Jan;91(1):1-13. View Related Products by Target Src |
| Molecular Formula | C21H19NO5 |
|---|---|
| Molecular Weight | 365.385 |