1831135-21-7

1831135-21-7 structure

Name: ML378
Chemical Name: ML378
CAS Number: 1831135-21-7
Molecular Formula: C₂₅H₃₂ClN₅O₆
Molecular Weight: 534.01
Create Date: 2020-01-11 16:54:51
Modify Date: 2024-01-14 22:45:14
ML378 (CID71710938;JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively; also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively.

Name	ML378

Description	ML378 (CID71710938;JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively; also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively.
References	References 1. Hulce JJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase

Molecular Formula	C₂₅H₃₂ClN₅O₆
Molecular Weight	534.01