ML378

Modify Date: 2024-01-14 22:45:14

ML378 structure	Common Name	ML378
	CAS Number	1831135-21-7	Molecular Weight	534.01
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₂ClN₅O₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ML378

ML378 (CID71710938;JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively; also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively.

Name	ML378

Description	ML378 (CID71710938;JJH-254) is an in vivo active carbamate-based dual inhibitor of lysophospholipase LYPLA1 (APT1) and LYPLA2 (APT2) with IC50 of 122 nM and 245 nM, repectively; also inhibits ABHD6 with IC50 of 3.15 nM, and displays 13-fold and >40-fold selectivity over FAAH and 20SHs respectively.
References	References 1. Hulce JJ, et al. Probe Reports from the NIH Molecular Libraries Program [Internet]. View Related Products by Target Phospholipase