1859189-54-0

1859189-54-0 structure

Name: BNM-III-170
Chemical Name: BNM-III-170
CAS Number: 1859189-54-0
Molecular Formula: C₂₁H₂₄ClFN₆O₂
Molecular Weight: 446.911
Create Date: 2020-01-11 17:17:25
Modify Date: 2024-03-04 10:44:43
BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).

Name	BNM-III-170

Description	BNM-III-170 is a small-molecule CD4-mimetic compound that enhances vaccine efficacy against HIV-1 challenge in vivo; binds the HIV-1 gp120 Env and promotes conformational changes similar to those induced by CD4, exposing conserved Env elements to antibodies; synergizes with antibodies elicited by monomeric HIV-1 gp120 to protect monkeys from multiple high-dose intrarectal challenges with a heterologous simian-human immunodeficiency virus (SHIV).
References	References 1. Madani N, et al. Nat Commun. 2018 Jun 18;9(1):2363. View Related Products by Target HIV

Molecular Formula	C₂₁H₂₄ClFN₆O₂
Molecular Weight	446.911