2226201-97-2

2226201-97-2 structure

Name: KSC-34
Chemical Name: KSC-34
CAS Number: 2226201-97-2
Molecular Formula: C₂₁H₂₈ClN₇O
Molecular Weight: 429.953
Catalog: Research Areas Neurological Disease
Create Date: 2020-01-12 14:06:50
Modify Date: 2024-01-09 09:23:48
KSC-34 (PDIA1 inhibitor KSC-34) is a potent, selective protein disulfide isomerase A1 (PDIA1) inhibitor, 30-fold selectivity for the A-site over the A' site; displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 × 103 M-1 s-1 and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins; significantly decreases the rate of secretion of a destabilized, amyloidogenic antibody light chain, thereby minimizing pathogenic amyloidogenic extracellular proteins in treated cells.

Name	KSC-34

Description	KSC-34 (PDIA1 inhibitor KSC-34) is a potent, selective protein disulfide isomerase A1 (PDIA1) inhibitor, 30-fold selectivity for the A-site over the A' site; displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 × 103 M-1 s-1 and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins; significantly decreases the rate of secretion of a destabilized, amyloidogenic antibody light chain, thereby minimizing pathogenic amyloidogenic extracellular proteins in treated cells.
References	References 1. Cole KS, et al. Biochemistry. 2018 Apr 3;57(13):2035-2043. View Related Products by Target Protein Disulfide Isomerase (PDI)

Molecular Formula	C₂₁H₂₈ClN₇O
Molecular Weight	429.953