2226201-97-2
2226201-97-2 structure
- Name: KSC-34
- Chemical Name: KSC-34
- CAS Number: 2226201-97-2
- Molecular Formula: C21H28ClN7O
- Molecular Weight: 429.953
- Catalog: Research Areas Neurological Disease
- Create Date: 2020-01-12 14:06:50
- Modify Date: 2024-01-09 09:23:48
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KSC-34 (PDIA1 inhibitor KSC-34) is a potent, selective protein disulfide isomerase A1 (PDIA1) inhibitor, 30-fold selectivity for the A-site over the A' site; displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 × 103 M-1 s-1 and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins; significantly decreases the rate of secretion of a destabilized, amyloidogenic antibody light chain, thereby minimizing pathogenic amyloidogenic extracellular proteins in treated cells.
| Name | KSC-34 |
|---|
| Description | KSC-34 (PDIA1 inhibitor KSC-34) is a potent, selective protein disulfide isomerase A1 (PDIA1) inhibitor, 30-fold selectivity for the A-site over the A' site; displays time-dependent inhibition of PDIA1 reductase activity in vitro with a kinact/ KI of 9.66 × 103 M-1 s-1 and is selective for PDIA1 over other members of the PDI family, and other cellular cysteine-containing proteins; significantly decreases the rate of secretion of a destabilized, amyloidogenic antibody light chain, thereby minimizing pathogenic amyloidogenic extracellular proteins in treated cells. |
|---|---|
| References | References 1. Cole KS, et al. Biochemistry. 2018 Apr 3;57(13):2035-2043. View Related Products by Target Protein Disulfide Isomerase (PDI) |
| Molecular Formula | C21H28ClN7O |
|---|---|
| Molecular Weight | 429.953 |