- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: NSC368262
- Price:
- Purity: 98.0%
- Stocking Period: 10 Day
- Contact: Huang
- DC Chemicals Limited
- China
- Product Name: NSC 368262
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g $150.0/10ml
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: NSC 368262
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Stocking Period: 1 Day
- Contact: Tony Lai
299421-08-2
299421-08-2 structure
- Name: NSC 368262
- Chemical Name: NSC 368262
- CAS Number: 299421-08-2
- Molecular Formula: C22H22N2O6
- Molecular Weight: 410.426
- Create Date: 2020-01-12 11:06:49
- Modify Date: 2024-02-04 17:15:28
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NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers; also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100 uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines, impressively inhibits tumor growth in mouse models.
| Name | NSC 368262 |
|---|
| Description | NSC 368262 is a selective STAT3 inhibitor that alkylates Cys468 in Stat3, blocks the DNA-binding activity of phosphorylated Stat3 homodimers with IC50 of 10-50 uM, without inhibiting the DNA-binding of phosphorylated Stat1 homodimers; also disrupts the DNA-binding activity of Stat1/Stat3 heterodimers (IC50=50-100 uM), blocks accumulation of activated Stat3 in the nucleus in tumor cell lines, impressively inhibits tumor growth in mouse models. |
|---|---|
| References | References 1. Buettner R, et al. ACS Chem Biol. 2011 May 20;6(5):432-43. View Related Products by Target STAT |
| Molecular Formula | C22H22N2O6 |
|---|---|
| Molecular Weight | 410.426 |