441289-66-3
441289-66-3 structure
- Name: VU714
- Chemical Name: VU714
- CAS Number: 441289-66-3
- Molecular Formula: C22H23ClN2O
- Molecular Weight: 366.889
- Create Date: 2020-01-12 01:32:49
- Modify Date: 2024-01-19 17:10:23
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A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays; inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM).
| Name | VU714 |
|---|
| Description | A potent inwardly rectifying K+ channel Kir7.1 inhibitor with IC50 of 5.6 uM in T1+ flux assays; inhibits other Kir channels with a rank order potency of Kir4.1 (IC50=13 µM) > Kir1.1 (IC50=16 µM) > Kir6.2/SUR1 (IC50=30 µM) > Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 (IC50 > 30 µM). |
|---|---|
| References | References 1. Kharade SV, et al. Mol Pharmacol. 2017 Sep;92(3):338-346. 2. Swale DR, et al. ACS Chem Neurosci. 2016 Jul 20;7(7):1013-23. View Related Products by Target Potassium Channel |
| Molecular Formula | C22H23ClN2O |
|---|---|
| Molecular Weight | 366.889 |