920849-78-1
920849-78-1 structure
- Name: PIN1 inhibitor VS10
- Chemical Name: PIN1 inhibitor VS10
- CAS Number: 920849-78-1
- Molecular Formula: C21H15NO4S
- Molecular Weight: 377.414
- Create Date: 2020-01-16 12:26:12
- Modify Date: 2024-01-18 23:56:54
-
PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM, displays >2-fold more potency than ATRA; reduces cancer cell viability of ovarian cancer cell lines with IC50 of 53.9-76.4 uM; targets PIN1 to the proteasome, and induces PIN1 protein degradation in NIH3T3 fibroblasts, also shows inhibitory effects on PIN1 target proteins (cyclin D1, pSer473-Akt and β-catenin) in the OVCAR3 cell line.
| Name | PIN1 inhibitor VS10 |
|---|
| Description | PIN1 inhibitor VS10 is a novel potent small molecule inhibitor of PIN1 (peptidyl-prolyl cis-trans isomerase, NIMA-interacting 1), inhibits human PIN1 isomerization with IC50 of 13.4 uM, displays >2-fold more potency than ATRA; reduces cancer cell viability of ovarian cancer cell lines with IC50 of 53.9-76.4 uM; targets PIN1 to the proteasome, and induces PIN1 protein degradation in NIH3T3 fibroblasts, also shows inhibitory effects on PIN1 target proteins (cyclin D1, pSer473-Akt and β-catenin) in the OVCAR3 cell line. |
|---|---|
| References | References 1. Russo Spena C, et al. J Cell Physiol. 2019 Jan 29. doi: 10.1002/jcp.28224. View Related Products by Target Other Targets |
| Molecular Formula | C21H15NO4S |
|---|---|
| Molecular Weight | 377.414 |