1203480-93-6
1203480-93-6 structure
- Name: SRTCX1003
- Chemical Name: SRTCX1003
- CAS Number: 1203480-93-6
- Molecular Formula: C23H23N5O3S
- Molecular Weight: 449.529
- Create Date: 2020-01-20 19:18:56
- Modify Date: 2024-09-09 17:04:58
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SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner, decreases the production of the proinflammatory cytokines TNFα and IL-12 in acute mouse model of LPS-induced inflammation.
| Name | SRTCX1003 |
|---|
| Description | SRTCX1003 (SRTCX-1003) is a small molecule activator of SIRT1 (STAC) with EC1.5 of 0.61 uM, enhances deacetylation of cellular p65 protein with IC50 of 1.42 uM in cellular p65 acetylation assay; suppresses TNFα-induced NF-κB transcriptional activation and reduction of LPS-stimulated TNFα secretion in a SIRT1-dependent manner, decreases the production of the proinflammatory cytokines TNFα and IL-12 in acute mouse model of LPS-induced inflammation. |
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| References | References 1. Yang H, et al. PLoS One. 2012;7(9):e46364. 2. Kim SY, et al. PLoS One. 2015 Jul 15;10(7):e0133448. View Related Products by Target Sirtuin |
| Molecular Formula | C23H23N5O3S |
|---|---|
| Molecular Weight | 449.529 |