1319725-20-6
1319725-20-6 structure
- Name: Peptide P60
- Chemical Name: Peptide P60
- CAS Number: 1319725-20-6
- Molecular Formula: C95H132N24O20S2
- Molecular Weight: 1994.369
- Create Date: 2020-01-20 15:16:56
- Modify Date: 2024-01-13 15:25:05
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Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT, inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation; induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection.
| Name | Peptide P60 |
|---|
| Description | Peptide P60 (FOXP3 inhibitor P60) is a 15-mer synthetic peptide, cell-permeable inhibitor of FOXP3, binds specifically to FOXP3; inhibits murine and human-derived Treg and improves effector T cell stimulation, overcomes the inhibitory effect of FOXP3 on the activity of the transcription factors NF-κB and NFAT, inhibits upregulation of mRNA for Foxp3 and IL-10 on effector T cells and enhances mRNA for IFN-γ after anti-CD3 stimulation; induces a scurfy-like disease in newborn mice, improves vaccine efficacy in mice model of CT26 tumor and HCV infection. |
|---|---|
| References | References 1. Casares N, et al. J Immunol. 2010 Nov 1;185(9):5150-9. View Related Products by Target Other Targets |
| Molecular Formula | C95H132N24O20S2 |
|---|---|
| Molecular Weight | 1994.369 |