1361993-03-4
1361993-03-4 structure
- Name: FAAH-IN-2
- Chemical Name: FAAH-IN-2
- CAS Number: 1361993-03-4
- Molecular Formula: C19H18BrFN2O3
- Molecular Weight: 421.266
- Create Date: 2020-01-11 09:31:53
- Modify Date: 2022-01-20 19:22:26
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A potent, selective, noncovalent FAAH inhibitor with IC50 of 28 nM toward human FAAH and 100 nM toward rat FAAH; demonstrates an excellent selectivity profile against a panel of cannabinoid related targets, including CB1, CB2, and VR1; demonstrates a unique nonmechanism-based inhibition of FAAH activity, which is distinct from almost all known FAAH inhibitors; shows excellent PK properties with a low clearance of 0.4 L/h/Kg and a high bioavailability of 92%.
| Name | FAAH-IN-2 |
|---|
| Description | A potent, selective, noncovalent FAAH inhibitor with IC50 of 28 nM toward human FAAH and 100 nM toward rat FAAH; demonstrates an excellent selectivity profile against a panel of cannabinoid related targets, including CB1, CB2, and VR1; demonstrates a unique nonmechanism-based inhibition of FAAH activity, which is distinct from almost all known FAAH inhibitors; shows excellent PK properties with a low clearance of 0.4 L/h/Kg and a high bioavailability of 92%. |
|---|---|
| References | References 1. Min X, et al. Proc Natl Acad Sci U S A. 2011 May 3;108(18):7379-84. View Related Products by Target FAAH |
| Molecular Formula | C19H18BrFN2O3 |
|---|---|
| Molecular Weight | 421.266 |