1382782-16-2
1382782-16-2 structure
- Name: mGlu5 PAM 4k
- Chemical Name: mGlu5 PAM 4k
- CAS Number: 1382782-16-2
- Molecular Formula: C18H15FN4O2
- Molecular Weight: 338.342
- Create Date: 2020-01-19 20:03:55
- Modify Date: 2024-01-07 11:06:09
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A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM; displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8; shows antipsychotic-like activity in vivo and for treatment of schizophrenia.
| Name | mGlu5 PAM 4k |
|---|
| Description | A potent, selective, CNS penetrant and orally bioavailable mGlu5 positive allosteric modulator that potentiates human mGlu5 with EC50 of 130 nM; displays 50-fold selectivity over mGlu3, and no activity against mGlu1/2/4/6/7/8; shows antipsychotic-like activity in vivo and for treatment of schizophrenia. |
|---|---|
| References | References 1. Conde-Ceide S, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):429-434. View Related Products by Target mGluR |
| Molecular Formula | C18H15FN4O2 |
|---|---|
| Molecular Weight | 338.342 |