1391107-89-3
1391107-89-3 structure
- Name: BM-1197
- Chemical Name: BM-1197
- CAS Number: 1391107-89-3
- Molecular Formula: C53H59ClF4N6O7S4
- Molecular Weight: 1131.774
- Create Date: 2020-01-19 22:00:55
- Modify Date: 2024-03-06 21:33:05
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BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1; exerts potent growth-inhibitory activity in 7 of 12 small cell lung cancer cell lines tested and induces mechanism-based apoptotic cell death, induces complete and long-lasting tumor regression in vivo.
| Name | BM-1197 |
|---|
| Description | BM-1197 is a potent, specific dual inhibitor of Bcl-2 and Bcl-xL with Ki of <1 nM, shows >1,000-fold selectivity over Mcl-1; exerts potent growth-inhibitory activity in 7 of 12 small cell lung cancer cell lines tested and induces mechanism-based apoptotic cell death, induces complete and long-lasting tumor regression in vivo. |
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| References | References 1. Bai L, et al. PLoS One. 2014 Jun 5;9(6):e99404. 2. Ye L, et al. Tumour Biol. 2015 May;36(5):3447-55. 3. Acasigua GA, et al. Oral Oncol. 2015 Sep;51(9):839-47. View Related Products by Target Bcl-2 |
| Molecular Formula | C53H59ClF4N6O7S4 |
|---|---|
| Molecular Weight | 1131.774 |