1431884-83-1
1431884-83-1 structure
- Name: MPK-09
- Chemical Name: MPK-09
- CAS Number: 1431884-83-1
- Molecular Formula: C24H34O6
- Molecular Weight: 418.53
- Create Date: 2020-01-20 09:42:56
- Modify Date: 2024-01-10 10:21:27
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A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator; exhibits potent cytotoxic activity against BT474 (p53 E285K) cell line (IC50=0.6 uM) as compared to wt p53 A549 (IC50=2.8 uM) and HeLa (IC50 = 4 uM) cells; enhances PARP cleavage, activates caspase 3 expressions and induces apoptosis.
| Name | MPK-09 |
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| Description | A highly potent, selective mutant p53 (R175H, R249S, R273H, R273C) reactivator; exhibits potent cytotoxic activity against BT474 (p53 E285K) cell line (IC50=0.6 uM) as compared to wt p53 A549 (IC50=2.8 uM) and HeLa (IC50 = 4 uM) cells; enhances PARP cleavage, activates caspase 3 expressions and induces apoptosis. |
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| References | References 1. Metri PK, et al. ACS Chem Biol. 2013 Jul 19;8(7):1429-34. View Related Products by Target MDM2-p53 |
| Molecular Formula | C24H34O6 |
|---|---|
| Molecular Weight | 418.53 |