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  • DC Chemicals Limited
  • China
  • Product Name: DFL 23448
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1445753-16-1

1445753-16-1 structure
1445753-16-1 structure
  • Name: DFL 23448
  • Chemical Name: DFL 23448
  • CAS Number: 1445753-16-1
  • Molecular Formula: C12H10FN5OS
  • Molecular Weight: 291.304
  • Create Date: 2020-01-20 10:33:56
  • Modify Date: 2024-02-22 19:51:00
  • A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats.

Name DFL 23448
Description A novel potent, selective TRPM8 channel antagonist with IC50 of 10 and 21 nM in hTRPM8 HEK293 cells activated by Cooling Agent 10 or cold; exhibits limited activity (IC50 >10 μM) at TRPV1, TRPA1, TRPV4 and at various G protein-coupled receptors; reduces icilin-induced "wet dog-like" shakes, reduces bladder overactivity in awake rats.
References References 1. Mistretta FA, et al. J Pharmacol Exp Ther. 2016 Jan;356(1):200-11. View Related Products by Target TRP Channel
Molecular Formula C12H10FN5OS
Molecular Weight 291.304