1482518-95-5
1482518-95-5 structure
- Name: NMS-P645
- Chemical Name: NMS-P645
- CAS Number: 1482518-95-5
- Molecular Formula: C28H38ClN5O2
- Molecular Weight: 512.095
- Create Date: 2020-01-20 15:38:55
- Modify Date: 2023-01-14 12:20:48
-
NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively; exhibits excellent selectivity against a large panel of kinases; reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments; induces a significant anti-proliferative response in PCa cells combined with GDC-0941.
| Name | NMS-P645 |
|---|
| Description | NMS-P645 is a novel selective inhibitor of pan-Pim kinases with IC50 of 3/73/12 nM for Pim1/2/3, respectively; exhibits excellent selectivity against a large panel of kinases; reverse PIM1-mediated pro-survival signals in prostate cells, such as activation of STAT3 through Tyr705 phosphorylation and resistance to taxane-based treatments; induces a significant anti-proliferative response in PCa cells combined with GDC-0941. |
|---|---|
| References | References 1. Casuscelli F, et al. Bioorg Med Chem. 2013 Dec 1;21(23):7364-80. 2. Mologni L, et al. J Cancer. 2017 Jan 1;8(1):140-145. View Related Products by Target Pim |
| Molecular Formula | C28H38ClN5O2 |
|---|---|
| Molecular Weight | 512.095 |