1644134-60-0
1644134-60-0 structure
- Name: ADM 12
- Chemical Name: ADM 12
- CAS Number: 1644134-60-0
- Molecular Formula: C11H21NO4S3
- Molecular Weight: 327.48
- Create Date: 2020-01-20 18:53:56
- Modify Date: 2024-01-07 16:15:03
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ADM 12 (ADM_12;ADM12) is a second lipoic-containing, selective TRPA1 antagonist with IC50 of 7.3 uM for the inhibition of 30 uM menthol-induced currents in cell assay; displays little to no activity for TRPM8 and TRPV4; significantly and persistently reduces mechanical facial allodynia in rats, has potential for treatment of orofacial pain; also reverts oxaliplatin-induced neuropathy and reduces pancreatic cancer cells malignancy by inhibiting carbonic anhydrase IX (CA IX) with Ki of 650 nM, reduces CA IX-mediated acidosis.
| Name | ADM 12 |
|---|
| Description | ADM 12 (ADM_12;ADM12) is a second lipoic-containing, selective TRPA1 antagonist with IC50 of 7.3 uM for the inhibition of 30 uM menthol-induced currents in cell assay; displays little to no activity for TRPM8 and TRPV4; significantly and persistently reduces mechanical facial allodynia in rats, has potential for treatment of orofacial pain; also reverts oxaliplatin-induced neuropathy and reduces pancreatic cancer cells malignancy by inhibiting carbonic anhydrase IX (CA IX) with Ki of 650 nM, reduces CA IX-mediated acidosis. |
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| References | References 1. Gualdani R, et al. ACS Chem Neurosci. 2015 Mar 18;6(3):380-5. 2. Fragai M, et al. J Med Chem. 2017 Nov 9;60(21):9003-9011. 3. Demartini C, et al. J Headache Pain. 2017 Sep 7;18(1):94. View Related Products by Target TRP Channel |
| Molecular Formula | C11H21NO4S3 |
|---|---|
| Molecular Weight | 327.48 |