1644134-60-0

1644134-60-0 structure

Name: ADM 12
Chemical Name: ADM 12
CAS Number: 1644134-60-0
Molecular Formula: C₁₁H₂₁NO₄S₃
Molecular Weight: 327.48
Create Date: 2020-01-20 18:53:56
Modify Date: 2024-01-07 16:15:03
ADM 12 (ADM_12;ADM12) is a second lipoic-containing, selective TRPA1 antagonist with IC50 of 7.3 uM for the inhibition of 30 uM menthol-induced currents in cell assay; displays little to no activity for TRPM8 and TRPV4; significantly and persistently reduces mechanical facial allodynia in rats, has potential for treatment of orofacial pain; also reverts oxaliplatin-induced neuropathy and reduces pancreatic cancer cells malignancy by inhibiting carbonic anhydrase IX (CA IX) with Ki of 650 nM, reduces CA IX-mediated acidosis.

Name	ADM 12

Description	ADM 12 (ADM_12;ADM12) is a second lipoic-containing, selective TRPA1 antagonist with IC50 of 7.3 uM for the inhibition of 30 uM menthol-induced currents in cell assay; displays little to no activity for TRPM8 and TRPV4; significantly and persistently reduces mechanical facial allodynia in rats, has potential for treatment of orofacial pain; also reverts oxaliplatin-induced neuropathy and reduces pancreatic cancer cells malignancy by inhibiting carbonic anhydrase IX (CA IX) with Ki of 650 nM, reduces CA IX-mediated acidosis.
References	References 1. Gualdani R, et al. ACS Chem Neurosci. 2015 Mar 18;6(3):380-5. 2. Fragai M, et al. J Med Chem. 2017 Nov 9;60(21):9003-9011. 3. Demartini C, et al. J Headache Pain. 2017 Sep 7;18(1):94. View Related Products by Target TRP Channel

Molecular Formula	C₁₁H₂₁NO₄S₃
Molecular Weight	327.48