1801163-44-9

1801163-44-9 structure

Name: ZINC 39395747
Chemical Name: ZINC 39395747
CAS Number: 1801163-44-9
Molecular Formula: C₁₂H₁₁N₃O₂S₂
Molecular Weight: 293.359
Create Date: 2020-01-11 17:43:49
Modify Date: 2024-01-13 13:13:00
A novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM; significantly increases NO bioavailability in renal vascular cells, augments renal blood flow, and decreases systemic blood pressure in response to vasoconstrictors in spontaneously hypertensive rats.

Name	ZINC 39395747

Description	A novel potent derivative of propylthiouracil that functions as a cell-active inhibitor of cytochrome b5 reductase 3 (CYB5R3) with IC50 of 9.14 uM; significantly increases NO bioavailability in renal vascular cells, augments renal blood flow, and decreases systemic blood pressure in response to vasoconstrictors in spontaneously hypertensive rats.
References	References 1. Rahaman MM, et al. J Biol Chem. 2015 Jul 3;290(27):16861-72. View Related Products by Target Other Targets

Molecular Formula	C₁₂H₁₁N₃O₂S₂
Molecular Weight	293.359