2043074-64-0

2043074-64-0 structure

Name: ABX-1431 hydrochloride
Chemical Name: ABX-1431 hydrochloride
CAS Number: 2043074-64-0
Molecular Formula: C₂₀H₂₃ClF₉N₃O₂
Molecular Weight: 543.859
Create Date: 2020-01-12 11:01:51
Modify Date: 2024-09-29 15:44:27
ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. Pain Phase 1 Clinical

Name	ABX-1431 hydrochloride

Description	ABX-1431 (ABX1431) is a highly potent, selective, orally available, CNS-penetrant monoacylglycerol lipase (MGLL) with IC50 of 14 nM (hMGLL); displays 23-fold selectivity for MGLL versus ABHD6 and CES1c, as well as exquisite selectivity of against other members of the serine hydrolase class; inhibits MGLL activity in rodent brain (ED50=0.5-1.4 mg/kg), increases brain 2-AG concentrations, and suppresses pain behavior in the rat formalin pain model. Pain Phase 1 Clinical
References	References 1. Cisar JS, et al. J Med Chem. 2018 Aug 1. doi: 10.1021/acs.jmedchem.8b00951. View Related Products by Target Monoacylglycerol Lipase (MAGL) Pain

Molecular Formula	C₂₀H₂₃ClF₉N₃O₂
Molecular Weight	543.859