2083618-79-3
2083618-79-3 structure
- Name: PDZ1i
- Chemical Name: PDZ1i
- CAS Number: 2083618-79-3
- Molecular Formula: C28H26N8O
- Molecular Weight: 538.568
- Catalog: Signaling Pathways JAK/STAT Signaling EGFR
- Create Date: 2020-01-20 15:10:55
- Modify Date: 2024-08-10 10:11:44
-
PDZ1i (113B7) is a specific inhibitor of MDA-9/Syntenin activity that inhibits MDA-9/Syntenin binding to EGFRvIII; selectively binds with micromolar affinity to the PDZ1 domain of MDA-9/Syntenin, with no affinity for PDZ2 domain of MDA-9/Syntenin; reduces invasion gains in GBM cells following radiation, inhibits crucial GBM signaling involving FAK and mutant EGFR, EGFRvIII, and abrogated gains in secreted proteases, MMP-2 and MMP-9, following radiation; results in smaller, less invasive tumors and enhanced survival in an in vivo glioma model.
| Name | PDZ1i |
|---|
| Description | PDZ1i (113B7) is a specific inhibitor of MDA-9/Syntenin activity that inhibits MDA-9/Syntenin binding to EGFRvIII; selectively binds with micromolar affinity to the PDZ1 domain of MDA-9/Syntenin, with no affinity for PDZ2 domain of MDA-9/Syntenin; reduces invasion gains in GBM cells following radiation, inhibits crucial GBM signaling involving FAK and mutant EGFR, EGFRvIII, and abrogated gains in secreted proteases, MMP-2 and MMP-9, following radiation; results in smaller, less invasive tumors and enhanced survival in an in vivo glioma model. |
|---|---|
| References | References 1. Kegelman TP, et al. Proc Natl Acad Sci U S A. 2017 Jan 10;114(2):370-375. View Related Products by Target Other Targets |
| Molecular Formula | C28H26N8O |
|---|---|
| Molecular Weight | 538.568 |