2158296-45-6
2158296-45-6 structure
- Name: KRAS-G12C inhibitor 13
- Chemical Name: KRAS-G12C inhibitor 13
- CAS Number: 2158296-45-6
- Molecular Formula: C30H36N6O3
- Molecular Weight: 528.657
- Create Date: 2020-01-11 21:22:49
- Modify Date: 2024-01-09 12:13:05
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KRAS-G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays; displays no significant activity against non-G12C cell lines with IC50 of >16 uM; demonstrates KRAS-G12C target engagement in vivo and antitumor efficacy in the MIA PaCa-2 tumor xenograft models.
| Name | KRAS-G12C inhibitor 13 |
|---|
| Description | KRAS-G12C inhibitor 13 is a potnt, irreversible, covalent and in vivo-active inhibitor of KRAS-G12C, suppresses ERK phosphorylation with IC50 of 70 nM in H358 cell assays; displays no significant activity against non-G12C cell lines with IC50 of >16 uM; demonstrates KRAS-G12C target engagement in vivo and antitumor efficacy in the MIA PaCa-2 tumor xenograft models. |
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| References | References 1. Jay B. Fell, et al. Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.8b00382. View Related Products by Target Ras |
| Molecular Formula | C30H36N6O3 |
|---|---|
| Molecular Weight | 528.657 |