Name | IT-603 |
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Description | A small molecule inhibitor of the NF-κB family member c-Rel with IC50 of 3 uM in EMSA assays; inhibits human diffuse large B-cell lymphoma (DLBCL) cell line with IC50 of 18 uM, binds c-Rel directly and changes the conformation of the protein, inhibiting DNA binding and transcriptional activity. |
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References | References 1. Shono Y, et al. Cancer Discov. 2014 May;4(5):578-91. View Related Products by Target NF-κB |
Molecular Formula | C11H9BrN2O3S |
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Molecular Weight | 329.168 |