319492-82-5
319492-82-5 structure
- Name: GAK inhibitor 49
- Chemical Name: GAK inhibitor 49
- CAS Number: 319492-82-5
- Molecular Formula: C20H22N2O5
- Molecular Weight: 370.405
- Catalog: Research Areas Infection
- Create Date: 2020-01-11 17:52:51
- Modify Date: 2024-01-15 17:30:41
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GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K); shows binding to only GAK and RIPK2 in an unbiased MIB/MS experiment in cell lysate.
| Name | GAK inhibitor 49 |
|---|
| Description | GAK inhibitor 49 is a potent, selective, ATP-competitive inhibitor of cyclin G-associated kinase (GAK, cell IC50=56 nM) with favourable NAK family selectivity (AAK1, STK16, BMP2K); shows binding to only GAK and RIPK2 in an unbiased MIB/MS experiment in cell lysate. |
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| References | References 1. Asquith CRM, et al. ChemMedChem. 2018 Jan 8;13(1):48-66. 2. Pu SY, et al. J Med Chem. 2018 Jul 16. doi: 10.1021/acs.jmedchem.8b00613. View Related Products by Target Other Targets |
| Molecular Formula | C20H22N2O5 |
|---|---|
| Molecular Weight | 370.405 |
| Hazard Codes | Xi |
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