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325990-63-4

325990-63-4 structure
325990-63-4 structure
  • Name: Lethal toxin inhibitor DN1
  • Chemical Name: Lethal toxin inhibitor DN1
  • CAS Number: 325990-63-4
  • Molecular Formula: C14H12FN3O
  • Molecular Weight: 257.268
  • Create Date: 2020-01-12 13:10:53
  • Modify Date: 2024-10-05 15:24:46
  • Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively; protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation, also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.

Name Lethal toxin inhibitor DN1
Description Lethal toxin inhibitor DN1 is a small molecule that reduces the cytotoxicity of anthrax lethal toxin (LT) an inhibitor of LT-induced pyroptosis, acts as an antagonist of GPCR receptors type-1 angiotensin II receptor (AGTR1) and apelin receptor (APLNR) with IC50 of 1.958 and 2.280 uM, respectively; protected cells irrespectively of LT concentration and reduced the pathogenicity of an additional bacterial exotoxin and several viruses, does not prevent LT internalization and catalytic activity or caspase-1 activation, also reduced the susceptibility of Drosophila melanogaster to toxin-associated bacterial infections.
References References 1. Hartmann S, et al. ACS Infect Dis. 2018 Nov 5. doi: 10.1021/acsinfecdis.8b00231. View Related Products by Target Bacterial
Molecular Formula C14H12FN3O
Molecular Weight 257.268