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  • DC Chemicals Limited
  • China
  • Product Name: MI-223
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

907166-59-0

907166-59-0 structure
907166-59-0 structure
  • Name: MI-223
  • Chemical Name: MI-223
  • CAS Number: 907166-59-0
  • Molecular Formula: C23H18ClN3O3
  • Molecular Weight: 419.865
  • Create Date: 2020-01-19 20:28:56
  • Modify Date: 2024-04-11 11:17:54
  • MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.

Name MI-223
Description MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib.
References References 1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516. View Related Products by Target Bcl-2
Molecular Formula C23H18ClN3O3
Molecular Weight 419.865