MI-223
Modify Date: 2024-04-11 11:17:54
MI-223 structure
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Common Name | MI-223 | ||
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| CAS Number | 907166-59-0 | Molecular Weight | 419.865 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C23H18ClN3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MI-223MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib. |
| Name | MI-223 |
|---|
| Description | MI-223 (NSC 320223) is a small molecule that specifically binds to Mcl-1 with Kd of 160 nM, inhibits HR DNA repair and sensitizes cancer cells to DNA replication agents; not only disrupts the Mcl-1/Ku complex, but also potently inhibits HR activity in both H1299 and U2OS DR-GFP cells in a dose-dependent manner, sensitizes cancer cells to hydroxyurea- or olaparib-induced DNA replication stress; exhibits a strong synergy against lung cancer in vivo combined with Olaparib. |
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| References | References 1. Chen G, et al. J Clin Invest. 2018 Jan 2;128(1):500-516. View Related Products by Target Bcl-2 |
| Molecular Formula | C23H18ClN3O3 |
|---|---|
| Molecular Weight | 419.865 |